Developmental & Epileptic Encephalopathies

DEEs are a heterogeneous group of rare and ultra-rare epilepsy syndromes that manifest with seizures, behavioral disturbances, or EEG abnormalities that can directly worsen cognition and behavior. These disorders are often progressive and are highly resistant to treatment.

These syndromes involve:

  • Impaired development (developmental encephalopathies)
  • Regression of developmental progress (epileptic encephalopathies)

Examples of DEEs include early myoclonic encephalopathy, epileptic encephalopathy with continuous spike and wave during sleep, and certain syndromes including Ohtahara, West, Landau-Kleffner, Lennox-Gastaut, Doose and Dravet. Treatment of seizures or EEG abnormalities may improve the cognitive or behavioral deficits and reduce the seizures.

Where can I find more information on DEE?

Epilepsy Foundation: Ohtahara Syndrome Information

Epilepsy Foundation: West’s Syndrome Information

Epilepsy Foundation: Dravet Syndrome Information

Epilepsy Foundation: Doose Syndrome Information

Epilepsy Foundation: Landau-Kleffner Information

Epilepsy Foundation: Lennox-Gaustaut Syndrome Information

Dravet Syndrome Foundation

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